What is the significance of the placement of the heart in the thoracic cavity and successful CPR?

-Some athletes, seeking a competitive edge, may resort to blood doping. How would you explain blood doping? What information would you provide to discourage athletes from blood doping?
The said athlete goes ahead and practices blood doping anyway. During a race she falls under cardiac arrest and requires CPR.
-How is CPR accomplished? What is the significance of the placement of the heart in the thoracic cavity and successful CPR?

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