Discuss how (and why) novel vaccine formats are being introduced to replace traditional protein-based formats

The discipline is Medical Biotechnology.
Essay topic: By describing our current understanding of the principles of human immune responses, discuss why vaccination has become a major part of human health programmes across the globe (50%). Using key examples, discuss how (and why) novel vaccine formats are being introduced to replace traditional protein-based formats (50%).
Please go into as much scientific detail as possible.
Reference format is Biomedical Vancouver, for example use (
Maximum word count is 1600, please use figures wherever possible.

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