abd dx and tx plans nurs 623 essays

abd dx and tx plans nurs 623 essays

abd dx and tx plans nurs 623 essays
Acute Gastroenteritis
Acute infection causing inflammation of the stomach and intestinal lining resulting in vomiting, diarrhea, and fever. Infection is by fecal-oral route or respiratory route. Pathogens invade the intestinal mucosa, resulting in a decreased area available for fluid absorption.
Viruses (most common), bacteria, and parasites are responsible.

Rotavirus most common in age <1 but found in adults too. The other 3 most common pathogens in adults are: norovirus, enteric adenovirus, and astrovirus. Bacterial infections are less common, but usually more severe. Campylobacter jejuni most common in children Salmonella most common cause of food borne illness in US Other common pathogens: shigella, Escherichia coli, Yersinia enterocolitica, clostridium difficile Parasitic Giardia Iamblia most common parasitic agent in US Cryptosporidium abd dx and tx plans nurs 623 essays ORDER A PLAGIARISM-FREE PAPER HERE Risk factors Improper handwashing and food preparation, daycare center attendance, recent use of antibiotics or hospitalization (C. difficile common), lack of sanitation, immunocompromised status, recent travel to developing countries Assessment findings Hyperactive bowel sounds, diarrhea (3 or more loose stools in 24 hours), blood in stool, white cells in stool (common with salmonella, shigella, and campylobacter), nausea and vomiting usually precede diarrhea, anorexia, fever, tenesmus (strong urge to defecate caused by and anal sphincter spasm), and fecal incontinence with C. difficile, abdominal cramps, dehydration (poor skin turgor, dry mucus membranes, flattened or sunken fontanels, tachycardia, tachypnea, oliguria), lethargy, pale skin color Differential diagnosis Viral, bacterial, parasitic, inflammatory bowel disease, medication/food intolerances, appendicitis, IBS, fecal impaction Diagnostic studies Usually none unless symptoms are severe and last > 48 hours,
stool for WBC: rare scattered leukocytes are normal; may suggest crohn’s disease, ulcerative colitis, ischemic colitis, shigella, salmonella, campylobacter
stool cultures: shigella, salmonella, campylobacter, E. coli most commonly identified
blood or mucus present in stool
stool for ova and parasites
urinalysis, culture, and sensitivity
abd dx and tx plans nurs 623 essays
in infants and elderly consider assessment for dehydration: BUN, specific gravity, electrolytes

Prevention
Hygiene, avoidance of risk factors, Shigella: culture all symptomatic contacts and treat those with positive stool cultures; report to local health department
Nonpharmacological management

Correct dehydration, orally if possible
Mild dehydration (3-5% volume loss): 50 mL/kg or 5 teaspoons per pound over 4 hours
Moderate dehydration (6-9% volume loss): 100 mL/kg or 10 teaspoons/pound over 4 hours
Rehydrating with soft drinks, gelatin, and apple juice is not advisable due to the high carbs, low electrolyte composition; commercially prepared rehydration products help avoid this problem Pedialyte, CeraLyte, Infalyte
Age appropriate diet ASAP
Reintroduce solid foods within 24 hours of onset of diarrhea
BRAT diet no longer recommended because it provides inadequate protein, fat, and calories
May develop temporary lactose intolerance and post infectious irritable bowel syndrome (IBS)
Monitor oral intake, urine output, and bowel movements, count wet diapers

Pharmacologic Management
Use of antidiarrheal agents is discouraged; the offending agent must be excreted.

aureus- antibiotics not recommended

Salmonella- antibiotics not recommended because it prolongs carrier state y slowing excretion or organisms, treatment recommended (Bactrim or ciprofloxacin for patients with valvular heart disease, immunocompromised states.
Shigella- Bactrim BID for 3-5 days; if acquired outside US ciprofloxacin for 10 days

coli- Bactrim Bid for 3 days, may use ciprofloxacin in adults

Campylobacter- erythromycin QID for 5 days or cipro BID for 7 days
Giardia (Protozoa)- Metronidazole 250 mg TID for 5-7 days

Difficile- Metronidazole 500 mg 3-4 times daily for 10-14 days for mild to moderate; vancomycin 125 mg every 6 hours for 10-14 days for first episode; fecal transplant for resistance/recurrence. Questran for diarrhea

Antiemetic
Promethazine adult 12.5-25 mg every 4-6 hours prn; children 2 years or older 0.5 mg/kg at 4-6 hr intervals max 25 mg

May cause fatal respiratory depression in children. Do not use in children under 2
Pregnancy category C
Cautious use in dehydrated patient
Cautious use in sleep apnea, asthma, lower respiratory disorders, glaucoma, GI or urinary obstruction
Potentiates CNS depression
If given IM, must be a deep IM injection

Selective 5-HT3 receptor antagonist
Ondansetron adult 8 mg q 8 hours; children 4-11 years 4 mg q 4 hours

For prevention of nausea/vomiting
Not recommended for children under 4 years of age
N/V associated with chemotherapy

Pregnancy/Lactation Considerations
Antibiotics indicated when there is a bacterial pathogen identified, refer if there is dehydration, intractable symptoms, or bloody diarrhea
Consultation/referral
Parenteral rehydration for intractable symptoms, neurologic symptoms, severe abdominal pain
Follow-up
Telephone contact within 24 hours, 3 days
abd dx and tx plans nurs 623 essays
Expected course
Both viral and bacterial gastroenteritis is usually self-limiting and resolves without medication in 5 days unless patient is at age extremes or immunocompromised, Salmonella and C. difficile infections: diarrhea may continue for up to 2 weeks
Possible complications
Cardiovascular from dehydration and acidosis, colonic perforation/septicemia, carrier state abd dx and tx plans nurs 623 essays.
 
Appendicitis
Inflammation of the veriform appendix, which is a projection from the apex of the cecum. Obstruction of the appendix secondary to stool, inflammation, stricture, foreign body, or neoplasm. The obstructed lumen prevents drainage. The resultant increased pressure decreases mucosal blood flow, and the appendix becomes hypoxic. Most common between ages 5-50 years, males>females.
Risk Factors
Family history, abdominal neoplasm
Assessment findings
Abdominal pain, usually severe and initially throughout the abdomen, or periumbilical area, later becomes localized to the right lower quadrant (RLQ). Anorexia, abdominal pain, nausea, and vomiting are most common symptoms (in this order). Constipation and diarrhea occur after the pain. Maximum abdominal tenderness and rigidity occurs over the right rectus muscle (McBurney’s point). Psoas sign: pain with right thigh extension. Obturator sign: pain with internal rotation of flexed right thigh. abd dx and tx plans nurs 623 essays. Fever, usually 99-101F (37.2-38.3 C). Patients frequently flex the right lower extremity when supine to relieve muscle tension. May have urinary frequency, urgency, and dysuria. Decreased bowel sounds. Elderly may present with weakness, anorexia, tachycardia, and abdominal distention.
A rectal exam should be performed on all patients with suspected appendicitis. Retrocecal appendix presents with tenderness on rectal exam.
A pelvic exam on all females with lower abdominal pain to rule out PID, adnexal mass, ectopic pregnancy, or uterine pathology.
Differential diagnosis
Mittelschmerz, ruptured etopic pregnancy, PID, gastroenteritis, gastric ulcer, duodenal ulcer, cholecystitis, urinary tract infection, Inflammatory bowel disease, recurrent abdominal pain, renal calculi
Diverticulitis, ileitis, inflammatory bowel disease and some GYN disorders can present with right sided abdominal pain.
Diagnostic studies

Urinalysis: may be positive for RBC and leukocytes
CBC: elevated WBC count indicates possible perforation
Urine pregnancy test: negative
KUB: may show gas filled appendix
CT scan: diagnostic test of choice in adults
Ultrasound is imaging study of choice in children
abd dx and tx plans nurs 623 essays

Nonpharmacologic management

Keep NPO
Instruct to refrain from using laxative, enemas, or from applying heat to abdomen
Prompt surgery is the treatment of choice: appendectomy

Pharmacological management
Preoperative antibiotics may be prescribed by surgeon (ex cefoxitin)
Consultant/referral
Prompt surgical referral
Follow-up
Routine postoperative assessment: 2 weeks, 6 weeks. May require postoperative antibiotics if perforation has occurred
Expected course
Quick recovery usually follows surgery. Activity should be restricted for 2-6 weeks
Possible complications
Ruptured appendix (often manifested by cessation of pain), abscess, peritonitis
abd dx and tx plans nurs 623 essays
Cholecystitis
Inflammation of the gallbladder usually associated with gallstone disease; can be acute or chronic. Gallstone obstructs the gallbladder-cystic duct junction; results in inflammation (90-95%) and acute pain. In a smaller number of cases, gallbladder inflammation occurs without stone formation. Obstruction of common bile duct can cause jaundice, light colored stools, and biliary colic. Obstruction of pancreatic duct can produce pancreatitis, pain over the abdomen, nausea and vomiting. Gallbladder sludge. Incidence increases with age and BMI; most common in ages 50-70 years females>males (2:1), very common in Native Americans.
Risk Factors
Pregnancy, rapid weight loss, obesity, gallstones, surgery or trauma, sickle cell anemia, parenteral alimentation over prolonged period.
Assessment findings
Patients are usually ill appearing, febrile, and tachycardic, murphy’s sign: inspiratory arrest with deep palpation of right upper quadrant (RUQ) (classic sign), RUQ pain, may be unremitting, with or without rebound pain, may radiate to right shoulder or subscapular area. Nausea and vomiting/anorexia. Attack follows meal (especially high fat) by 1-6 hours. Low grade fever, palpable RUQ mass. abd dx and tx plans nurs 623 essays.
A patient with acute cholecystitis usually lies very still because peritoneal inflammation is present and worsens with movement.
Differential diagnosis
PUD, cardiac disease, pancreatitis, hepatitis, bowel obstruction, appendicitis
Fatty food intolerance that produces pain, belching, a few minutes after eating is NOT typical of gallbladder disease.
Diagnostic studies

Ultrasound is most sensitive and specific to test to diagnose cholecystitis
Ultrasound demonstrates presence of gallstones, thickening of wall of gallbladder (4-5 mm), fluid, and enlargement.
HIDA scan helpful if ultrasound is negative but patient is suspected of having cholecystitis (positive scan demonstrates gallbladder disease if the gallbladder is unable to be visualized due to cystic duct obstruction)
Magnetic Resonance Cholangiopancreatography (MRCP, type of MRI that provides detailed images of hepatobiliary and pancreatic systems)
Endoscopic retrograde Cholangiopancreatography (ERCP) used to see biliary and pancreatic ducts to detect common bile stones. Usually this is performed after a MRCP for choledocholithiasis.

A HIDA scan cholescintigraphy is indicated if the diagnosis of gallbladder disease is still considered and the ultrasound is negative. abd dx and tx plans nurs 623 essays.
Prevention
Avoid risk factors, during parenteral feedings, administer cholestyramine (Questran) daily.
Nonpharmacological management

Severe attacks: nothing by mouth
Mild attacks: avoid fatty meals
Nasogastric tube for persistent nausea or abdominal distention
Laparoscopic or open cholecystectomy within 72 hours of diagnosis

Pharmacological management
Endogenous bile acids
Bile acid (Actigall) adults: 8-10 mg/kg per day in 2-3 divided doses; prevention 300 mg twice daily

Pregnancy category B
Not for calcified, radio-opaque or radiolucent bile pigment stones
Obtain sonogram at 6 and 12 months
After complete dissolution, repeat sonogram in 1-3 months then discontinue
Used to prevent gallstone formation in patients undergoing rapid weight loss
Measure liver enzymes at 1 and 3 months, then q 6 months while taking

Bile acid (Urso forte) adults: 13-15 mg/kg per day in 2-4 divided doses

Pregnancy category B
Take with food
Reduced absorption with bile acid sequestrants and aluminum containing antacids
Not for calcified, radio-opaque or radiolucent bile pigment stones
Obtain sonogram at 6 and 12 months
After complete dissolution repeat sonogram in 1-3 months then discontinue
Used to prevent gallstone formation in patients undergoing rapid weight loss
Measure liver enzymes at 1 and 3 months, then q 6 months while taking
abd dx and tx plans nurs 623 essays

Antiemetic
Promethazine adult 12.5-25 mg every 4-6 hours prn; children 2 years or older 0.5 mg/kg at 4-6 hr intervals max 25 mg

May cause fatal respiratory depression in children. Do not use in children under 2
Pregnancy category C
Cautious use in dehydrated patient
Cautious use in sleep apnea, asthma, lower respiratory disorders, glaucoma, GI or urinary obstruction
Potentiates CNS depression
If given IM, must be a deep IM injection

Selective 5-HT3 receptor antagonist
Ondansetron adult 8 mg q 8 hours; children 4-11 years 4 mg q 4 hours

For prevention of nausea/vomiting
Not recommended for children under 4 years of age
N/V associated with chemotherapy

Consultation/referral
Outpatient if mild symptoms, surgeon if biliary colic >6 hr, toxic appearing, or intractable pain.
Follow-up
Throughout postoperative period
Expected course
Stones may recur in bile ducts after cholecystectomy
Possible complications
Empyema of the gallbladder: bacterial invasion of the gallbladder. Emphysematous cholecystitis: infection with a gas-forming bacterium. Perforation: requires aggressive fluid replacement, antibiotics and emergency surgical exploration. Cholecystenteric fistula: gallbladder perforates into duodenum or colon; should be treated as a bowel obstruction with fluid replacement, nasogastric suction, and surgical exploration.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Inflammatory bowel disease
Inflammatory bowel diseases are chronic disorders of the GI tract distinguished by the recurrent inflammatory involvement of the intestinal segments. Teo main types are Crohns disease and ulcerative colitis.
Crohn’s disease
Chronic, slowly progressive transmural inflammation of the gastrointestinal tract, small intestine (most common), and/or large intestine, often involving the terminal ileum; disease ranges from mild to refractory in severity. Typically, several locations of the intestines with sections in between are unaffected. Idiopathic. Females>males, % have family history, Caucasians>African-Americans or Asians, peak age at onset is 15-25 years, then smaller peak at 55-65 years. Three to six-fold increased incidence in Ashkenazi Jewish population.
Risk factors
Family history, cigarette smoking
Assessment findings
Diarrhea (including nocturnal), fever, abdominal pain and tenderness, ulcers of the intestine or mouth, fatigue, weight loss, abdominal mass, fistulas, intestinal obstruction (uncommon), hematochezia, megacolon, extracolonic disease: uveitis, arthritis, dermatitis, sclerosing cholangitis (<10%), joint swelling, hepatosplenomegaly, bone age in children usually delayed by 2 years The hallmark of Crohns disease are fatigue, abdominal pain, and prolonged diarrhea with or without bleeding, weight loss, and fever. Differential diagnosis Ulcerative colitis, NSAID adverse effects, enteritis, intestinal pathogenic bacteria, malignancy, IBS, appendicitis, PUD, renal colic, celiac sprue, diverticulitis Diagnostic studies Colonoscopy with biopsy: submucosal inflammation with pseudopolyps, edema, and strictures; biopsy often reveals granulomatous inflammation Flexible sigmoidoscopy CT scan or CT enterography MRI or MRI enterography Antiglycan antibody: elevated in 75% of cases Barium X-rays Capsule endoscopy if suspicious of diagnosis despite other tests being negative Sedimentation rate: elevated CBC: anemia Albumin: below normal if severe disease Electrolytes: imbalances B12, folate: deficient Stool for leukocytes, culture and sensitivity, C. difficile, ova and parasites to rule out other causes for symptoms Fecal occult blood test Nonpharmacologic management Maintain nutrition and weight: May be helpful to decrease fat and increase fiber to treat diarrhea; fiber can be a trigger as well Low lactose diet for small intestine involvement Avoid caffeine, alcohol, nuts, seeds Sitz baths helpful if perirectal disease present Drainage of perirectal abscess if present Manage extracolonic manifestations Refer to crohns and colitis foundation of America for information and support www.ccfa.org Surgery when indicated Abscess Intestinal obstruction Ostomy placement Pharmacologic management Mesalamine (asacol, pentasa, rowasa) or sulfasalazine (Azulfidine, salazopyrin) is used for maintenance and is taken daily Antibiotics (if perirectal involvement): metronidazole (flagyl) reduces bacteria, granuloma formation Corticosteroids short-term for moderate to severe disease or budesonide x 8 weeks Immunosuppressant such as Imuran or mercaptopurine methotrexate for severe, progressive disease Biologics such as humira or remicade alone or in conjunction with Imuran Folate supplement while taking sulfasalazine, which inhibits folate absorption Antispasmotics and antidiarrheals may be helpful Pregnancy/lactation considerations Pregnancy not contraindicates, long term sulfasalazine therapy is associates with reversible sterility in males Consultation/referral Gastroenterologist Follow-up Frequency dependent on severity Monitor weight, symptoms, CBC, sedimentation rate, Vitamin B12, folate levels Changes in weight, increase in severity of symptoms, and colonoscopy findings are helpful in determining need to increase or decrease medications Endoscopy indicated if symptoms change Annual liver function tests Expected course Chronic illness with recurrences and exacerbations. Surgery usually needed every 4-7 years for the average patient. Full activities and normal, but often shortened life can be expected. Possible complications Fistulae, colon perforation, toxic megacolon, adenocarcinoma, malnutrition, bowel obstruction, ulcers, anal fissure    Diverticulitis Diverticula, outpouchings that can occur along the wall of the large intestine, become infected, with resultant inflammation. Aerobic and anaerobic bacteria invade diverticula. Chronic, low grade inflammation contributes to recurrence of diverticulitis. Diverticulosis, the presence of diverticula, is common; especially in Western cultures where low fiber diets predominate and incidence increases with age. 2,200-3,000/100,000 in US. Risk factors Low fiber diet, low residue diet, diverticulosis, age >50, smoking, NSAID/Aspirin use
Assessment findings
Abdominal pain (due to tension in the wall of the colon), typically left lower quadrant, with or without palpable mass. Rebound tenderness, board like rigidity, anorexia, nausea and vomiting, diarrhea, constipation, bloating, gas, abdominal distention, fever, chills abd dx and tx plans nurs 623 essays.
Differential diagnosis
Gynecologic disorders, urologic disorders, appendicitis, ulcerative colitis, lactose intolerance, Crohns disease, IBS, colon cancer, infective colitis, ischemic colitis
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Diagnostic studies

Abdominal computed tomography (CT) scan, with or without contrast, is least expensive and provides the most information about presence, location, and extent of inflammation but cannot detect presence of bleeding. Not indicated if recurrent disease with good response to treatment
Barium enema used to diagnosis diverticulosis
CBC: leukocytosis
Sed rate elevated
Colonoscopy/ flexible sigmoidoscopy to rule out malignancy, ulcerative colitis, or ischemic colitis

Colonoscopy and flexible sigmoidoscopy are usually contraindicated during acute diverticular episode. Generally, a colonoscopy is performed about 6 weeks after the acute episode to allow the colon to heal before insufflating the colon.
Prevention
High fiber diet (but not proven)
Many patients have been advised to avoid seeds, nuts, corn because they could become lodged in a diverticula and produce diverticulitis. Most colorectal surgeons do not believe that these should be avoided but some patients swear they are triggers. abd dx and tx plans nurs 623 essays.
Nonpharmacologic management

Bowel rest and relaxation
NPO during acute episode, advance to clear liquids in small volume at frequent intervals for 3 days, low residue diet 5-7 days, then slowly advance to high fiber diet
Surgery may be indicated if patient experiences frequent recurrences
Recommend high fiber diet

Pharmacologic management
Ciprofloxacin and metronidazole given in combination for outpatient treatment
IV antibiotics given for severe symptoms/infection
Anti-infectives
Ciprofloxacin 500 mg bid for 7-14 days

Pregnancy category C
Quinolones are associated with increased risk of tendon rupture in all ages
Cipro XR is only indicated for UTI. Use ciprofloxacin for diverticulitis
Dosage adjustment needed for renal impairment
Quinolones should not be used for pediatric patients
Drug interactions with theophylline, methylxanthines, glyburide, NSAIDS and others

Metronidazole adult: 500 mg q 6-8 hr for 7-14 days max: 4g/24 hr; 750 mg tid for 7-10 days

Pregnancy category B
Alcohol should be avoided while taking metronidazole and for at least 3 days after last dose
Potentiates the anticoagulant effect of warfarin and other anticoagulants
Dosage adjustment for renal impairment
abd dx and tx plans nurs 623 essays

Consultation/referral
Gastroenterologist if moderate or severe symptoms exist
Indications for surgical consult

Severe, repeated, or extensive disease
Carcinoma suspected
Abdominal drainage

Expected course
Symptoms completely resolve in 1-2 weeks, greater than 2/3 of patients fully recover without recurrence, and colon resection is almost always curative
Possible complications
Perforation, abscess formation, sepsis, enteroenteric or enterovesical fistula, peritonitis, bowel obstruction
 
Non-alcoholic fatty liver disease
A diagnosis of NAFLD can be made when other causes of liver disease have been excluded by either imaging or biopsy.
Thought to be related to “two hits theory”. First occurs due to insulin resistance and altered lipid metabolism resulting in fatty acids infiltrating the liver. Proinflammatory cytokines (tumor necrosis factor [TNF]-alpha and interleukin-6) and endotoxins are released causing oxidative stress and inflammation, and later steatohepatitis. Poor dietary choices (high cholesterol foods, sugary foods, especially fructose) can worsen the process. Inflammation causes more liver injury, which can result in fibrosis, and later cirrhosis and/or hepatocellular carcinoma. Three genes were discovered that have polymorphisms which contribute to the development of nonalcoholic steatohepatitis (NASH). In western countries, NAFLD is the most common liver disorder. 20% of the population is affected worldwide. 25% of Americans are affected. The most common form of liver disease for pediatric patients (3-11% od children) abd dx and tx plans nurs 623 essays.
Risk factors
Insulin resistance, metabolic syndrome, obesity, type 2 DM, CVD, HTN, dyslipidemia, particularly high triglycerides and/or low-density lipoprotein levels, male gender, older age, Hispanic ethnicity, genetic disposition
Assessment findings
Penetration of fat into liver cells (hepatic steatosis) that may result in inflammation and/or fibrosis of the liver. It can progress to cirrhosis. Disease is divided into nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). NASH is differentiated from NAFL because it is associated with significant hepatic inflammation.

Most are asymptomatic
Mild abdominal pain, particularly RUQ
Nausea
Fatigue
Dorsocervical lipohypertrophy
Elevated liver enzymes (particularly ALT> AST)
Jaundice
Pruritis
Hepatomegaly

Assessment should include a thorough review of onset of symptoms and social history (alcohol consumption, illicit drug use, history of blood transfusions, and sexual history).
Differential diagnosis
Alcohol fatty liver disease, viral hepatitis, starvation, drug related liver injury, pregnancy, autoimmune hepatitis, iron overload
Diagnostic studies

Ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI): all can identify hepatic steatosis
Transient elastography: used to determine degree of liver fibrosis
Gold standard for diagnosis is liver biopsy and should be considered for patients who have elevated liver enzymes
Laboratory studies
No biomarker currently available for diagnosis
Liver function test (LFTs): may be elevated
Ferritin and uric acid levels: may be elevated
Laboratory studies to exclude other liver diseases
Total protein
Alanine transaminase (ALT)
Aspartate transaminase (AST)
Alkaline phosphatase
Albumin
Total and direct bilirubin
Viral hepatitis serologies (Hepatitis A IgG/IgM, Hepatitis B surface antigen Hepatitis B surface antibody, hepatitis B core antibody, hepatitis C antibody)
Ferritin
Total iron (plasma)
Iron binding capacity
Fasting glucose
Hemoglobin A1C
Lipid panel, including low-density lipoprotein cholesterol
Prothrombin time
Autoimmune markers (serum gammaglobulin level, antinuclear antibody, antismooth muscle antibody, and anti-liver/kidney microsomal antibody-1).

Prevention
Adequate treatment of other comorbidities (diabetes, obesity, hyperlipidemia, hypertension). Good, balanced nutrition (avoidance of high sugary and fatty foods). Hepatitis A and B vaccinations. A high rate of fatal cardiovascular events occur in patients who have NAFL.
Nonpharmacologic management

Mainstay of treatment is lifestyle changes, including diet modifications and increasing physical activity
Avoid alcohol consumption
Dietary changes, including decreasing calorie intake, low fat/low cholesterol diet and avoiding trans fats and high fructose corn syrup
Exercise (moderate physical exercise 3-4 times per week)
>3% weight loss has been shown to reduce hepatic steatosis
Support groups have been proven helpful to make necessary lifestyle changes
Psychosocial therapy is available to help with weight loss
abd dx and tx plans nurs 623 essays

Pharmacologic management
There are no current medications FDA approved for the treatment of NASH
Consultation/referral

If steatohepatitis is found on liver biopsy, referral to a gastroenterologist/hepatologist is recommended
If cirrhosis is found on liver biopsy, consider referral to a hepatologist, preferably a transplant center

Follow-up
Close follow-up ad management of other comorbidities is suggested. Weight management and physical activity should be logged and discussed at every follow up visit.
Expected course
Most common cause of death in this patient group is related to cardiovascular related events. Patients with NASH have a higher risk of liver related mortality.
Possible complications
Hepatocellular carcinoma, cirrhosis
abd dx and tx plans nurs 623 essays
 
 
Gastroesophageal reflux (GER) Gastroesophageal Reflux Disease (GERD)
Gastroesophageal reflux (GER): movement of gastrointestinal contents up the esophagus or larynx facilitated by decreased lower esophageal sphincter (LES) tone. Some reflux is physiologic
Gastroesophageal reflux disease (GERD): gastric contents reflux into the esophagus or oropharynx and symptoms occur. abd dx and tx plans nurs 623 essays.
Affects up to a third of Americans at some time in their lives. Affects 81% of patients 60 years or older, common in pregnant patients. Recurrent vomiting occurs. Small minority of infants develop GERD. ER: common in pediatrics. GERD: little is known about prevalence in children and adolescents.
Risk factors
Factors which may reduce LES tone

Alcohol
Anticholinergic medications
Calcium channel blockers
Chocolate, peppermint
Fatty, spicy, and citrus foods
Hormones: estrogen, progesterone, glucagon, secretin
Obesity
Pregnancy
Meperidine
Nicotine
Theophylline

Childhood GERD predisposes GERD in adolescence and adulthood
Risk factors for GERD during childhood:

Neurologic disorder (cerebral palsy)
Congenital malformation (esophageal atresia or trachea-esophageal fistula)
Severe chronic pulmonary disease (cystic fibrosis)

Aging
Zenker’s diverticulum
Irritation of esophageal mucosa by

NSAIDS
Tetracycline
Quinidine
Caffeine

Increased gastric acid secretion: acidic foods
Delay in gastric emptying: fatty foods
Zollinger-Ellison syndrome
Obesity
Diabetes mellitus, diabetic gastroparesis
Assessment findings

Pyrosis (heartburn) is cardinal symptom, burning beneath sternum, typically postpradial and nocturnal
Regurgitation, (“sour, hot”): 60%
Chest pain: 33% send for cardiac workup
Dysphagia (present in longstanding heartburn): 15-20%
Esophageal pain referred to neck, mid back, and upper abdomen
Chronic cough, PND, clearing throat (common to have and all three)
Chronic sore throat/hoarseness
Erosion of teeth by acid
Ulceration: hematemesis, fatigue, anemia
Barrett’s esophagitis (small number of patients): replacement of the squamous epithelium of the esophagus by columnar epithelium, which may be further complicated by adenocarcinoma in 1-5% of cases
abd dx and tx plans nurs 623 essays

Infants

Recurring vomiting
Poor weight gain or weight loss
Irritability or excessive crying
Disturbed sleep
Dysphagia or refusal to eat
Arching of back during feeding
Respiratory problems/stridor
Apnea
Apparent life threatening events (ALTE)

Child or adolescent

Recurrent vomiting or regurgitation
Heartburn or chest pain
Hoarseness

Bilious vomiting and hematemesis are RED flags in children
Differential diagnosis
Cardiac disease, esophageal spasm or infection, cholelithiasis, PUD, lower respiratory infection: bronchitis, pneumonia, asthma, pulmonary edema
In infants and children consider gastrointestinal obstruction, gastrointestinal disorders, infectious disease, neurologic disorders, metabolic or endocrine disorders, renal conditions, toxic conditions, cardiac problems : chronic heart failure
Diagnostic studies

Patient with one episode of heartburn that responds well to nonpharmacologic and acid suppressant therapy may require no further investigation
Endoscopy necessary for patients with GERD symptoms who have not responded to empirical trial of PPI therapy
Endoscopy with biopsy necessary at presentation for patients with esophageal GERD syndrome with troublesome dysphagia
Manometry: motility test to determine LES and esophageal function
Ambulatory esophageal pH testing to detect pathologic reflux
Endoscopy to observe effects of esophagitis and obtain biopsy for histology
50% of symptomatic patients have NERD (nonerosive reflux disease)
Infants and children
History and physical sufficient to reliability diagnose GER, recognize complications, and initiate management in most infants with vomiting, older children with regurgitation and heartburn
Upper GI to evaluate presence of anatomic abnormalities
Esophageal pH monitoring: acid reflux
Endoscopy and biopsy assess presence and severity of esophagitis, strictures, and Barrett’s esophagus; exclude other disorders
Empiric medical therapy for a trial period to determine if GER is causing specific symptoms

Nonpharmacologic management
Education: physical causes of GERD, common aggravating and ameliorating factors, and lifestyle changes to control GERD:

Avoid recumbence until 2 hours after meals
Elevate head of bed, including entire chest
Reduce size of meals and amount of fat, acid, spices, caffeine, and sweets
Smoking cessation
Reduce alcohol consumption
Lose weight if indicated
Avoid stooping, bending after meals and tight fitting garments

Surgical interventions, crural tightening or fundoplication, reserved for patient with stricture, hemorrhage, barrett’s esophagitis, chronic aspiration or intractable symptoms
Infants

Milk thickening: reduces number of episodes of vomiting
Supine position to sleep to reduce risk of sudden infant death syndrome (SIDS)
Diet changes: hypoallergenic formula

Child or adolescent:

Position left side with head of bed elevated
Lifestyle changes
Avoid caffeine, chocolate, spicy foods
Avoid cigarette smoke and alcohol use
Weight control: obesity associated with GER
abd dx and tx plans nurs 623 essays

Pharmacologic management
Antacids
Calcium carbonate (tums) adult: chew 2-4 tabs as symptoms occur max 15 tabs/24 hrs

Pregnancy category C
Do not use maximum dosage for more than 2 weeks
FDA not evaluated and approved this OTC for reflux
Produces rapid relief of heartburn symptoms
Use with caution in patients with CHF, renal failure, edema, and cirrhosis
Blocks absorption of digoxin, tetracyclines, benzodiazepines, iron, and others

H2 antagonists
Cimetidine (Tagamet)adults an

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